Late-stage oxidative C(sp3)–H methylation
Author:
Publisher
Springer Science and Business Media LLC
Subject
Multidisciplinary
Link
http://www.nature.com/articles/s41586-020-2137-8.pdf
Reference45 articles.
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3. Barreiro, E. J., Kümmerle, A. E. & Fraga, C. A. M. The methylation effect in medicinal chemistry. Chem. Rev. 111, 5215–5246 (2011).
4. Leung, C. S., Leung, S. S. F., Tirado-Rives, J. & Jorgensen, W. L. Methyl effects on protein-ligand binding. J. Med. Chem. 55, 4489–4500 (2012).
5. Fauber, B. P. et al. Discovery of 1-{4-[3-fluoro-4-((3S,6R)-3-methyl-1,1-dioxo-6-phenyl-[1,2]thiazinan-2-ylmethyl)-phenyl]-piperazin-1-yl}-ethanone (GNE-3500): a potent, selective, and orally bioavailable retinoic acid receptor-related orphan receptor c (RORc or RORγ) inverse agonist. J. Med. Chem. 58, 5308–5322 (2015).
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