XFEL structures of the human MT2 melatonin receptor reveal the basis of subtype selectivity-Reference-Cited by-同舟云学术

XFEL structures of the human MT2 melatonin receptor reveal the basis of subtype selectivity

Published:2019-04-24 Issue:7755 Volume:569 Page:289-292
ISSN:0028-0836
Container-title:Nature
language:en
Short-container-title:Nature

Author:

Johansson Linda C.,Stauch Benjamin,McCorvy John D.,Han Gye Won,Patel Nilkanth,Huang Xi-Ping,Batyuk Alexander,Gati Cornelius,Slocum Samuel T.,Li Chufeng,Grandner Jessica M.,Hao Shuming,Olsen Reid H. J.,Tribo Alexandra R.,Zaare Sahba,Zhu Lan,Zatsepin Nadia A.,Weierstall Uwe,Yous Saïd,Stevens Raymond C.,Liu Wei,Roth Bryan L.,Katritch Vsevolod,Cherezov Vadim

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Link

http://www.nature.com/articles/s41586-019-1144-0.pdf

Reference47 articles.

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2. Reppert, S. M. et al. Molecular characterization of a second melatonin receptor expressed in human retina and brain: the Mel1b melatonin receptor. Proc. Natl Acad. Sci. USA 92, 8734–8738 (1995).

3. Liu, J. et al. MT1 and MT2 melatonin receptors: a therapeutic perspective. Annu. Rev. Pharmacol. Toxicol. 56, 361–383 (2016).

4. Bonnefond, A. et al. Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes. Nat. Genet. 44, 297–301 (2012).

5. Karamitri, A. et al. Type 2 diabetes-associated variants of the MT2 melatonin receptor affect distinct modes of signaling. Sci. Signal. 11, eaan6622 (2018).

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