Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing

Author:

Riva Laura,Yuan Shuofeng,Yin XinORCID,Martin-Sancho Laura,Matsunaga Naoko,Pache LarsORCID,Burgstaller-Muehlbacher SebastianORCID,De Jesus Paul D.,Teriete Peter,Hull Mitchell V.,Chang Max W.,Chan Jasper Fuk-Woo,Cao Jianli,Poon Vincent Kwok-Man,Herbert Kristina M.,Cheng Kuoyuan,Nguyen Tu-Trinh H.,Rubanov Andrey,Pu Yuan,Nguyen Courtney,Choi Angela,Rathnasinghe Raveen,Schotsaert MichaelORCID,Miorin Lisa,Dejosez Marion,Zwaka Thomas P.,Sit Ko-Yung,Martinez-Sobrido LuisORCID,Liu Wen-Chun,White Kris M.ORCID,Chapman Mackenzie E.,Lendy Emma K.,Glynne Richard J.,Albrecht RandyORCID,Ruppin Eytan,Mesecar Andrew D.ORCID,Johnson Jeffrey R.,Benner Christopher,Sun RenORCID,Schultz Peter G.,Su Andrew I.ORCID,García-Sastre AdolfoORCID,Chatterjee Arnab K.ORCID,Yuen Kwok-YungORCID,Chanda Sumit K.ORCID

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Reference68 articles.

1. Yang, X. et al. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study. Lancet Respir. Med. 8, 475–481 (2020).

2. Sbrissa, D., Naisan, G., Ikonomov, O. C. & Shisheva, A. Apilimod, a candidate anticancer therapeutic, arrests not only PtdIns(3,5)P2 but also PtdIns5P synthesis by PIKfyve and induces bafilomycin A1-reversible aberrant endomembrane dilation. PLoS ONE 13, e0204532 (2018).

3. Billich, A. Drug evaluation: apilimod, an oral IL-12/IL-23 inhibitor for the treatment of autoimmune diseases and common variable immunodeficiency. IDrugs 10, 53–59 (2007).

4. Cai, X. et al. PIKfyve, a class III PI kinase, is the target of the small molecular IL-12/IL-23 inhibitor apilimod and a player in Toll-like receptor signaling. Chem. Biol. 20, 912–921 (2013).

5. World_Health_Organization. Coronavirus Disease (COVID-19) Pandemic https://www.who.int/emergencies/diseases/novel-coronavirus-2019 (2020).

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