Structural insights into Ubr1-mediated N-degron polyubiquitination

Author:

Pan ManORCID,Zheng Qingyun,Wang Tian,Liang Lujun,Mao Junxiong,Zuo Chong,Ding Ruichao,Ai Huasong,Xie YuanORCID,Si DongORCID,Yu YuanyuanORCID,Liu LeiORCID,Zhao MingleiORCID

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Reference46 articles.

1. Chau, V. et al. A multiubiquitin chain is confined to specific lysine in a targeted short-lived protein. Science 243, 1576–1583 (1989).

2. Bartel, B., Wunning, I. & Varshavsky, A. The recognition component of the N-end rule pathway. EMBO J. 9, 3179–3189 (1990).

3. Komander, D. & Rape, M. The ubiquitin code. Annu. Rev. Biochem. 81, 203–229 (2012).

4. Chen, S. J., Wu, X., Wadas, B., Oh, J. H. & Varshavsky, A. An N-end rule pathway that recognizes proline and destroys gluconeogenic enzymes. Science 355, eaal3655 (2017).

5. Kim, J. M. et al. Formyl-methionine as an N-degron of a eukaryotic N-end rule pathway. Science 362, eaat0174 (2018).

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