Prophylactic TNF blockade uncouples efficacy and toxicity in dual CTLA-4 and PD-1 immunotherapy-Reference-Cited by-同舟云学术

Prophylactic TNF blockade uncouples efficacy and toxicity in dual CTLA-4 and PD-1 immunotherapy

Published:2019-05 Issue:7756 Volume:569 Page:428-432
ISSN:0028-0836
Container-title:Nature
language:en
Short-container-title:Nature

Author:

Perez-Ruiz Elisabeth,Minute Luna,Otano Itziar,Alvarez Maite,Ochoa Maria Carmen,Belsue Virginia,de Andrea Carlos,Rodriguez-Ruiz Maria Esperanza,Perez-Gracia Jose Luis,Marquez-Rodas Ivan,Llacer Casilda,Alvarez Martina,de Luque Vanesa,Molina Carmen,Teijeira Alvaro,Berraondo Pedro,Melero Ignacio

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Link

http://www.nature.com/articles/s41586-019-1162-y.pdf

Reference31 articles.

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3. Hellmann, M. D. et al. Nivolumab plus ipilimumab in lung cancer with a high tumor mutational burden. N. Engl. J. Med. 378, 2093–2104 (2018).

4. Wolchok, J. D. et al. Nivolumab plus ipilimumab in advanced melanoma. N. Engl. J. Med. 369, 122–133 (2013).

5. Curran, M. A., Montalvo, W., Yagita, H. & Allison, J. P. PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors. Proc. Natl Acad. Sci. USA 107, 4275–4280 (2010).

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