Pyrimidine inhibitors synergize with nucleoside analogues to block SARS-CoV-2-Reference-Cited by-同舟云学术

Pyrimidine inhibitors synergize with nucleoside analogues to block SARS-CoV-2

Published:2022-02-07 Issue:7904 Volume:604 Page:134-140
ISSN:0028-0836
Container-title:Nature
language:en
Short-container-title:Nature

Author:

Schultz David C.^ORCID,Johnson Robert M.^ORCID,Ayyanathan Kasirajan,Miller Jesse^ORCID,Whig Kanupriya^ORCID,Kamalia Brinda,Dittmar Mark^ORCID,Weston Stuart,Hammond Holly L.,Dillen Carly,Ardanuy Jeremy,Taylor Louis,Lee Jae Seung,Li Minghua,Lee Emily,Shoffler Clarissa^ORCID,Petucci Christopher,Constant Samuel,Ferrer Marc,Thaiss Christoph A.^ORCID,Frieman Matthew B.^ORCID,Cherry Sara^ORCID

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Link

https://www.nature.com/articles/s41586-022-04482-x.pdf

Reference27 articles.

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2. Huang, C. et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 395, 497–506 (2020).

3. Huchting, J. Targeting viral genome synthesis as broad-spectrum approach against RNA virus infections. Antivir. Chem. Chemother. 28, 2040206620976786 (2020).

4. Jordheim, L. P., Durantel, D., Zoulim, F. & Dumontet, C. Advances in the development of nucleoside and nucleotide analogues for cancer and viral diseases. Nat. Rev. Drug Discov. 12, 447–464 (2013).

5. Sheahan, T. P. et al. Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV. Nat. Commun. 11, 222 (2020).

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