UTX condensation underlies its tumour-suppressive activity-Reference-Cited by-同舟云学术

UTX condensation underlies its tumour-suppressive activity

Published:2021-09-15 Issue:7878 Volume:597 Page:726-731
ISSN:0028-0836
Container-title:Nature
language:en
Short-container-title:Nature

Author:

Shi Bi,Li Wei^ORCID,Song Yansu,Wang Zhenjia,Ju Rui,Ulman Aleksandra^ORCID,Hu Jing,Palomba Francesco^ORCID,Zhao Yanfang,Le John Philip,Jarrard William,Dimoff David,Digman Michelle A.^ORCID,Gratton Enrico,Zang Chongzhi,Jiang Hao^ORCID

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Link

https://www.nature.com/articles/s41586-021-03903-7.pdf

Reference62 articles.

1. Wang, L. & Shilatifard, A. UTX mutations in human cancer. Cancer Cell 35, 168–176 (2019).

2. Gozdecka, M. et al. UTX-mediated enhancer and chromatin remodeling suppresses myeloid leukemogenesis through noncatalytic inverse regulation of ETS and GATA programs. Nat. Genet. 50, 883–894 (2018).

3. Andricovich, J. et al. Loss of KDM6A activates super-enhancers to induce gender-specific squamous-like pancreatic cancer and confers sensitivity to BET inhibitors. Cancer Cell 33, 512–526.e8 (2018).

4. Morales Torres, C., Laugesen, A. & Helin, K. Utx is required for proper induction of ectoderm and mesoderm during differentiation of embryonic stem cells. PLoS ONE 8, e60020 (2013).

5. Wang, C. et al. UTX regulates mesoderm differentiation of embryonic stem cells independent of H3K27 demethylase activity. Proc. Natl Acad. Sci. USA 109, 15324–15329 (2012).

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