NOTUM from Apc-mutant cells biases clonal competition to initiate cancer-Reference-Cited by-同舟云学术

NOTUM from Apc-mutant cells biases clonal competition to initiate cancer

Published:2021-06-02 Issue:7863 Volume:594 Page:430-435
ISSN:0028-0836
Container-title:Nature
language:en
Short-container-title:Nature

Author:

Flanagan Dustin J.,Pentinmikko Nalle^ORCID,Luopajärvi Kalle,Willis Nicky J.^ORCID,Gilroy Kathryn,Raven Alexander P.,Mcgarry Lynn^ORCID,Englund Johanna I.^ORCID,Webb Anna T.,Scharaw Sandra^ORCID,Nasreddin Nadia^ORCID,Hodder Michael C.,Ridgway Rachel A.^ORCID,Minnee Emma,Sphyris Nathalie,Gilchrist Ella^ORCID,Najumudeen Arafath K.^ORCID,Romagnolo Beatrice,Perret Christine^ORCID,Williams Ann C.^ORCID,Clevers Hans^ORCID,Nummela Pirjo^ORCID,Lähde Marianne,Alitalo Kari^ORCID,Hietakangas Ville,Hedley Ann,Clark William,Nixon Colin^ORCID,Kirschner Kristina^ORCID,Jones E. Yvonne^ORCID,Ristimäki Ari,Leedham Simon J.,Fish Paul V.,Vincent Jean-Paul^ORCID,Katajisto Pekka^ORCID,Sansom Owen J.^ORCID

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Link

http://www.nature.com/articles/s41586-021-03525-z.pdf

Reference33 articles.

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2. Huels, D. J. et al. Wnt ligands influence tumour initiation by controlling the number of intestinal stem cells. Nat. Commun. 9, 1132 (2018).

3. Powell, S. M. et al. APC mutations occur early during colorectal tumorigenesis. Nature 359, 235–237 (1992).

4. Snippert, H. J. et al. Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells. Cell 143, 134–144 (2010).

5. Vermeulen, L. et al. Defining stem cell dynamics in models of intestinal tumor initiation. Science 342, 995–998 (2013).

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