In vivo CRISPR base editing of PCSK9 durably lowers cholesterol in primates
Author:
Musunuru KiranORCID, Chadwick Alexandra C., Mizoguchi Taiji, Garcia Sara P.ORCID, DeNizio Jamie E., Reiss Caroline W.ORCID, Wang Kui, Iyer Sowmya, Dutta Chaitali, Clendaniel VictoriaORCID, Amaonye MichaelORCID, Beach Aaron, Berth Kathleen, Biswas Souvik, Braun Maurine C., Chen Huei-Mei, Colace Thomas V., Ganey John D., Gangopadhyay Soumyashree A., Garrity RyanORCID, Kasiewicz Lisa N., Lavoie Jennifer, Madsen James A., Matsumoto Yuri, Mazzola Anne Marie, Nasrullah Yusuf S., Nneji Joseph, Ren Huilan, Sanjeev AthulORCID, Shay Madeleine, Stahley Mary R., Fan Steven H. Y., Tam Ying K., Gaudelli Nicole M.ORCID, Ciaramella Giuseppe, Stolz Leslie E., Malyala Padma, Cheng Christopher J., Rajeev Kallanthottathil G., Rohde Ellen, Bellinger Andrew M., Kathiresan SekarORCID
Publisher
Springer Science and Business Media LLC
Subject
Multidisciplinary
Reference50 articles.
1. Jinek, M. et al. A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. Science 337, 816–821 (2012). 2. Zetsche, B. et al. Cpf1 is a single RNA-guided endonuclease of a class 2 CRISPR-Cas system. Cell 163, 759–771 (2015). 3. Strecker, J. et al. Engineering of CRISPR–Cas12b for human genome editing. Nat. Commun. 10, 212 (2019). 4. Komor, A. C., Kim, Y. B., Packer, M. S., Zuris, J. A. & Liu, D. R. Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage. Nature 533, 420–424 (2016). 5. Gaudelli, N. M. et al. Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage. Nature 551, 464–471 (2017).
Cited by
480 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
|
|