The promise and challenge of therapeutic genome editing
Author:
Publisher
Springer Science and Business Media LLC
Subject
Multidisciplinary
Link
http://www.nature.com/articles/s41586-020-1978-5.pdf
Reference115 articles.
1. Jinek, M. et al. A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. Science 337, 816–821 (2012). This study demonstrates dual RNA-programmed DNA cutting by CRISPR–Cas9 and establishes a sgRNA format to direct Cas9 applications, providing a road map for genome editing in human, animal and plant cells.
2. Cong, L. et al. Multiplex genome engineering using CRISPR/Cas systems. Science 339, 819–823 (2013).
3. Mali, P. et al. RNA-guided human genome engineering via Cas9. Science 339, 823–826 (2013).
4. Jinek, M. et al. RNA-programmed genome editing in human cells. eLife 2, e00471 (2013).
5. Cho, S. W., Kim, S., Kim, J. M. & Kim, J.-S. Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease. Nat. Biotechnol. 31, 230–232 (2013).
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