Phase I trials of targeted anticancer drugs: a need to refocus
Author:
Publisher
Springer Science and Business Media LLC
Subject
Drug Discovery,Pharmacology,General Medicine
Link
http://www.nature.com/articles/nrd3909.pdf
Reference5 articles.
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2. Glassman, R. H. & Ratain, M. J. Biomarkers in early cancer drug development: limited utility. Clin. Pharmacol. Ther. 85, 134–135 (2009).
3. Kummar, S. et al. Phase 0 clinical trials: recommendations from the Task Force on Methodology for the Development of Innovative Cancer Therapies. Eur. J. Cancer 45, 741–746 (2009).
4. Goodwin, R. et al. Targeted agents: how to select winners in preclinical and early clinical studies? Eur. J. Cancer 48, 170–178 (2012).
5. Le Tourneau, C., Lee, J. J. & Siu, L. L. Dose escalation methods in Phase I cancer clinical trials. J. Natl Cancer Inst. 101, 708–720 (2009).
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