Parkin–phosphoubiquitin complex reveals cryptic ubiquitin-binding site required for RBR ligase activity-Reference-Cited by-同舟云学术

Parkin–phosphoubiquitin complex reveals cryptic ubiquitin-binding site required for RBR ligase activity

Published:2017-04-17 Issue:5 Volume:24 Page:475-483
ISSN:1545-9993
Container-title:Nature Structural & Molecular Biology
language:en
Short-container-title:Nat Struct Mol Biol

Author:

Kumar Atul,Chaugule Viduth K^ORCID,Condos Tara E C,Barber Kathryn R,Johnson Clare,Toth Rachel,Sundaramoorthy Ramasubramanian,Knebel Axel,Shaw Gary S,Walden Helen

Publisher

Springer Science and Business Media LLC

Subject

Molecular Biology,Structural Biology

Link

http://www.nature.com/articles/nsmb.3400.pdf

Reference63 articles.

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3. Kitada, T. et al. Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism. Nature 392, 605–608 (1998).

4. Valente, E.M. et al. Hereditary early-onset Parkinson's disease caused by mutations in PINK1 . Science 304, 1158–1160 (2004).

5. Chung, S.Y. et al. Parkin and PINK1 patient iPSC-derived midbrain dopamine neurons exhibit mitochondrial dysfunction and α-synuclein accumulation. Stem Cell Reports 7, 664–677 (2016).

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