Drug repurposing: sulfasalazine sensitizes gliomas to gamma knife radiosurgery by blocking cystine uptake through system Xc−, leading to glutathione depletion-Reference-Cited by-同舟云学术

Drug repurposing: sulfasalazine sensitizes gliomas to gamma knife radiosurgery by blocking cystine uptake through system Xc−, leading to glutathione depletion

Published:2015-03-23 Issue:49 Volume:34 Page:5951-5959
ISSN:0950-9232
Container-title:Oncogene
language:en
Short-container-title:Oncogene

Author:

Sleire L,Skeie B S,Netland I A,Førde H E,Dodoo E,Selheim F,Leiss L,Heggdal J I,Pedersen P-H,Wang J,Enger P Ø

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Genetics,Molecular Biology

Link

http://www.nature.com/articles/onc201560.pdf

Reference40 articles.

1. Stupp R, Mason WP, van den Bent MJ, Weller M, Fisher B, Taphoorn MJ et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 2005; 352: 987–996.

2. Cairns RA, Harris IS, Mak TW . Regulation of cancer cell metabolism. Nat Rev Cancer 2011; 11: 85–95.

3. Fruehauf JP, Meyskens FL Jr . Reactive oxygen species: a breath of life or death? Clin Cancer Res 2007; 13: 789–794.

4. Hayes JD, McMahon M . NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer. Trends Biochem Sci 2009; 34: 176–188.

5. Lluis JM, Buricchi F, Chiarugi P, Morales A, Fernandez-Checa JC . Dual role of mitochondrial reactive oxygen species in hypoxia signaling: activation of nuclear factor-{kappa}B via c-SRC and oxidant-dependent cell death. Cancer Res 2007; 67: 7368–7377.

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