The NEDD8 inhibitor MLN4924 increases the size of the nucleolus and activates p53 through the ribosomal-Mdm2 pathway-Reference-Cited by-同舟云学术

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The NEDD8 inhibitor MLN4924 increases the size of the nucleolus and activates p53 through the ribosomal-Mdm2 pathway

Published:2015-04-13 Issue:4 Volume:35 Page:415-426
ISSN:0950-9232
Container-title:Oncogene
language:en
Short-container-title:Oncogene

Author:

Bailly A,Perrin A,Bou Malhab L J,Pion E,Larance M,Nagala M,Smith P,O'Donohue M-F,Gleizes P-E,Zomerdijk J,Lamond A I,Xirodimas D P

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Genetics,Molecular Biology

Link

http://www.nature.com/articles/onc2015104.pdf

Reference67 articles.

1. Abidi N, Xirodimas DP . Regulation of cancer-related pathways by protein NEDDylation and strategies for the use of NEDD8 inhibitors in the clinic. Endocr Relat Cancer 2015; 22: T55–T70.

2. Enchev RI, Schulman BA, Peter M . Protein neddylation: beyond cullin-RING ligases. Nat Rev Mol Cell Biol 2014; 16: 30–44.

3. Watson IR, Irwin MS, Ohh M . NEDD8 pathways in cancer, Sine Quibus Non. Cancer Cell 2011; 19: 168–176.

4. Wang M, Medeiros BC, Erba HP, DeAngelo DJ, Giles FJ, Swords RT . Targeting protein neddylation: a novel therapeutic strategy for the treatment of cancer. Expert Opin Ther Targets 2011; 15: 253–264.

5. Liakopoulos D, Doenges G, Matuschewski K, Jentsch S . A novel protein modification pathway related to the ubiquitin system. EMBO J 1998; 17: 2208–2214.

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1. Ribosome heterogeneity in development and disease;Frontiers in Cell and Developmental Biology;2024-07-17

2. Redox-driven control of Yuh1/UCHL3 impacts mitochondrial health via NEDD8/Rub1 pathway;2024-05-21

3. Pevonedistat, a first-in-class NEDD8-activating enzyme inhibitor, sensitizes cancer cells to VSVΔ51 oncolytic virotherapy;Molecular Therapy;2023-11

4. CRISPR/Cas9-mediated knockout of the ubiquitin variant UbKEKS reveals a role in regulating nucleolar structures and composition;Biology Open;2023-09-15

5. Deneddylation of ribosomal proteins promotes synergy between MLN4924 and chemotherapy to elicit complete therapeutic responses;Cell Reports;2023-08

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