Toxin acidic residue evolutionary function-guided design of de novo peptide drugs for the immunotherapeutic target, the Kv1.3 channel-Reference-Cited by-同舟云学术

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Toxin acidic residue evolutionary function-guided design of de novo peptide drugs for the immunotherapeutic target, the Kv1.3 channel

Published:2015-05-08 Issue:1 Volume:5 Page:
ISSN:2045-2322
Container-title:Scientific Reports
language:en
Short-container-title:Sci Rep

Author:

Chen Zongyun,Hu Youtian,Hong Jing,Hu Jun,Yang Weishan,Xiang Fang,Yang Fan,Xie Zili,Cao Zhijian,Li Wenxin,Lin Donghai,Wu Yingliang

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Link

http://www.nature.com/articles/srep09881.pdf

Reference43 articles.

1. Beeton, C. et al. Kv1.3 channels are a therapeutic target for T cell-mediated autoimmune diseases. Proc Natl Acad Sci U S A 103, 17414–9 (2006).

2. Wulff, H. et al. The voltage-gated Kv1.3 K+ channel in effector memory T cells as new target for MS. J Clin Invest 111, 1703–13 (2003).

3. Li, Z. et al. Selective inhibition of CCR7− effector memory T cell activation by a novel peptide targeting Kv1.3 channel in a rat experimental autoimmune encephalomyelitis model. J Biol Chem 287, 29479–94 (2012).

4. Vennekamp, J. et al. Kv1.3-blocking 5-phenylalkoxypsoralens: a new class of immunomodulators. Mol Pharmacol 65, 1364–74 (2004).

5. Schmitz, A. et al. Design of PAP-1, a selective small molecule Kv1.3 blocker, for the suppression of effector memory T cells in autoimmune diseases. Mol Pharmacol 68, 1254–70 (2005).

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