Discovery of Potent VEGFR-2 Inhibitors based on Furopyrimidine and Thienopyrimidne Scaffolds as Cancer Targeting Agents-Reference-Cited by-同舟云学术

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Discovery of Potent VEGFR-2 Inhibitors based on Furopyrimidine and Thienopyrimidne Scaffolds as Cancer Targeting Agents

Published:2016-04-15 Issue:1 Volume:6 Page:
ISSN:2045-2322
Container-title:Scientific Reports
language:en
Short-container-title:Sci Rep

Author:

Aziz Marwa A.,Serya Rabah A. T.,Lasheen Deena S.,Abdel-Aziz Amal Kamal,Esmat Ahmed,Mansour Ahmed M.,Singab Abdel Nasser B.,Abouzid Khaled A. M.

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Link

http://www.nature.com/articles/srep24460.pdf

Reference61 articles.

1. Bridges, E. M. & Harris, A. L. The angiogenic process as a therapeutic target in cancer. Biochem Pharmacol 81, 1183–1191 (2011).

2. Saharinen, P., Eklund, L., Pulkki, K., Bono, P. & Alitalo, K. VEGF and angiopoietin signaling in tumor angiogenesis and metastasis. Trends Mol Med 17, 347–362 (2011).

3. Bergers, G. & Benjamin, L. E. Tumorigenesis and the angiogenic switch. Nat Rev Cancer 3, 401–410 (2003).

4. Gerhardt, H. VEGF and endothelial guidance in angiogenic sprouting. Organogenesis 4, 241–6 (2008).

5. Otrock, Z. K., Makarem, J. A. & Shamseddine, A. I. Vascular endothelial growth factor family of ligands and receptors: Review. Blood Cells, Mol. Dis 38, 258–268 (2007).

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