CpG methylation is maintained in human cancer cells lacking DNMT1

Author:

Rhee Ina,Jair Kam-Wing,Yen Ray-Whay Chiu,Lengauer Christoph,Herman James G.,Kinzler Kenneth W.,Vogelstein Bert,Baylin Stephen B.,Schuebel Kornel E.

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Reference30 articles.

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2. Jones,P. A. & Laird,P. W. Cancer epigenetics comes of age. Nature Genet. 21, 163– 167 (1999).

3. Schmutte,C., Yang,A. S., Nguyen,T. T., Beart,R. W. & Jones,P. A. Mechanisms for the involvement of DNA methylation in colon carcinogenesis. Cancer Res. 56, 2375 –2381 (1996).

4. Eads,C. A. et al. CpG island hypermethylation in human colorectal tumors is not associated with DNA methyltransferase overexpression. Cancer Res. 59, 2302–2306 ( 1999).

5. Li,E., Bestor,T. H. & Jaenisch, R. Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell 69, 915–926 (1992).

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