Author:
Zhao Hailong,Xiong Shuicai,Li Zhiwei,Wu Xuebiao,Li Lijuan
Abstract
AbstractAlthough numerous genetic studies have reported the link between
Val66Met in BDNF gene with smoking, the findings
remain controversial, mainly due to small-to-moderate sample sizes. The main aim of
current investigation is to explore whether the variant of Val66Met has any genetic
functions in the progress of smoking persistence. The Val-based dominant genetic
model considering Val/* (namely, Val/Val + Val/Met) and Met/Met as two genotypes
with comparison of the frequency of each genotype in current smokers and never
smokers. There were seven genetic association articles including eight independent
datasets with 10,160 participants were chosen in current meta-analytic
investigation. In light of the potent effects of ethnicity on homogeneity across
studies, we carried out separated meta-analyses according to the ancestry origin by
using the wide-used tool of Comprehensive Meta-analysis software (V 2.0). Our
meta-analyses results indicated that the Val66Met polymorphism was significantly
linked with smoking persistence based on either all the chosen samples (N = 10,160; Random and fixed models: pooled OR = 1.23;
95% CI = 1.03–1.46; P value = 0.012) or Asian
samples (N = 2,095; Fixed model: pooled
OR = 1.25; 95% CI = 1.01–1.54; P value = 0.044;
Random model: pooled OR = 1.25; 95% CI = 1.001–1.56; P value = 0.049). No significant clue of bias in publications or
heterogeneity across studies was detected. Thus, we conclude that the Val66Met
(rs6265) variant conveys genetic susceptibility to maintaining smoking, and smokers
who carry Val/* genotypes have a higher possibility of maintaining smoking than
those having Met/Met genotype.
Funder
National Natural
Science Foundation of China
Publisher
Springer Science and Business Media LLC
Subject
Pharmacology,Genetics,Molecular Medicine
Cited by
3 articles.
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