Transcriptional analysis of targets in multiple sclerosis
Author:
Publisher
Springer Science and Business Media LLC
Subject
Energy Engineering and Power Technology,Fuel Technology
Link
http://www.nature.com/articles/nri1108.pdf
Reference57 articles.
1. Chabas, D. et al. The influence of the proinflammatory cytokine, osteopontin, on autoimmune demyelinating disease. Science 294, 1731–1735 (2001). This study describes the sequencing of messenger RNA transcripts found in the brain using robotics. The biological role of osteopontin (OPN), one of the sequences that are found in the brain of patients with multiple sclerosis (MS), is described.
2. Lock, C. et al. Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis. Nature Med. 8, 500–508 (2002). This paper shows how oligonucleotide microarrays are used to assess mRNA transcripts in acute and chronic MS lesions. The biological roles of some of these transcripts, including those encoding G-CSF and Fcε receptor, are shown.
3. Robinson, W. H. et al. Antigen arrays for multiplex characterization of autoantibody responses. Nature Med. 8, 295–301 (2002).
4. Steinman, L. Multiple sclerosis: a two stage disease. Nature Immunol. 2, 762–765 (2001).
5. Steinman, L. Autoimmune disease. Sci. Am. 269, 106–114 (1993).
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