Fungal Metabolite, Epoxyquinol B, Crosslinks Proteins by Epoxy-thiol Conjugation-Reference-Cited by-同舟云学术

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Fungal Metabolite, Epoxyquinol B, Crosslinks Proteins by Epoxy-thiol Conjugation

Published:2008-02 Issue:2 Volume:61 Page:94-97
ISSN:0021-8820
Container-title:The Journal of Antibiotics
language:en
Short-container-title:J Antibiot

Author:

Kamiyama Hiroshi,Usui Takeo,Uramoto Masakazu,Takagi Hiroshi,Shoji Mitsuru,Hayashi Yujiro,Kakeya Hideaki,Osada Hiroyuki

Publisher

Springer Science and Business Media LLC

Subject

Drug Discovery,Pharmacology

Link

http://www.nature.com/articles/ja2008117.pdf

Reference11 articles.

1. Mateo C, Abian O, Fernández-Lorente G, Pedroche J, Fernández-Lafuente R, Guisan JM, Tam A, Daminati M . Epoxy sepabeads: a novel epoxy support for stabilization of industrial enzymes via very intense multipoint covalent attachment. Biotechnol Prog 18: 629–634 ( 2002)

2. Kakeya H, Onose R, Yoshida A, Koshino H, Osada H . Epoxyquinol B, a fungal metabolite with a potent antiangiogenic activity. J Antibiot 55: 829–831 ( 2002)

3. Kakeya H, Onose R, Koshino H, Yoshida A, Kobayashi K, Kageyama S, Osada H . Epoxyquinol A, a highly functionalized pentaketide dimer with antiangiogenic activity isolated from fungal metabolites. J Am Chem Soc 124: 3496–3497 ( 2004)

4. Kamiyama H, Kakeya H, Usui T, Nishikawa K, Shoji M, Hayashi Y, Osada H . Epoxyquinol B shows antiangiogenic and antitumor effects by inhibiting VEGFR2, EGFR, FGFR, and PDGFR. Oncology Res ( in press)

5. Karplus M . Contact electron-spin coupling of nuclear magnetic moments. J Chem Phys 30: 11–15 ( 1959)

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