Applications of nanotechnology for immunology
Author:
Publisher
Springer Science and Business Media LLC
Subject
Energy Engineering and Power Technology,Fuel Technology
Link
http://www.nature.com/articles/nri3488.pdf
Reference149 articles.
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5. Goldinger, S. M. et al. Nano-particle vaccination combined with TLR-7 and -9 ligands triggers memory and effector CD8+ T-cell responses in melanoma patients. Eur. J. Immunol. 42, 3049–3061 (2012). This Phase IIa clinical trial shows both the advantages and the potential limitations of using an improved MelQbG10 virus-like nanoparticle (30 nm) vaccine displaying MART1 on the surface together with integrated and exogenous TLR agonists for the enhanced generation of T H 1 cell responses and effector or memory CD8+ T cell activation in late stage cancer patients.
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