A calcium- and calpain-dependent pathway determines the response to lenalidomide in myelodysplastic syndromes
Author:
Publisher
Springer Science and Business Media LLC
Subject
General Biochemistry, Genetics and Molecular Biology,General Medicine
Link
http://www.nature.com/articles/nm.4127.pdf
Reference36 articles.
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2. List, A. et al. Myelodysplastic Syndrome-003 Study Investigators. Lenalidomide in the myelodysplastic syndrome with chromosome 5q deletion. N. Engl. J. Med. 355, 1456–1465 (2006).
3. Giagounidis, A.A. Lenalidomide for del(5q) and non-del(5q) myelodysplastic syndromes. Semin. Hematol. 49, 312–322 (2012).
4. Wei, S. et al. Lenalidomide promotes p53 degradation by inhibiting MDM2 auto-ubiquitination in myelodysplastic syndrome with chromosome 5q deletion. Oncogene 32, 1110–1120 (2013).
5. McDaniel, J.M., Pinilla-Ibarz, J. & Epling-Burnette, P.K. Molecular action of lenalidomide in lymphocytes and hematologic malignancies. Adv. Hematol. 2012, 513702 (2012).
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