Sustained Akt signaling in articular chondrocytes causes osteoarthritis via oxidative stress-induced senescence in mice
Author:
Publisher
Springer Science and Business Media LLC
Subject
Physiology,Histology,Endocrinology, Diabetes and Metabolism
Link
http://www.nature.com/articles/s41413-019-0062-y.pdf
Reference51 articles.
1. Glyn-Jones, S. et al. Osteoarthritis. Lancet 386, 376–387 (2015).
2. Manning, B. D. & Toker, A. AKT/PKB Signaling: navigating the network. Cell 169, 381–405 (2017).
3. Hollander, M. C., Blumenthal, G. M. & Dennis, P. A. PTEN loss in the continuum of common cancers, rare syndromes and mouse models. Nat. Rev. Cancer 11, 289–301 (2011).
4. Chen, W. S. et al. Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene. Genes Dev. 15, 2203–2208 (2001).
5. Fukai, A. et al. Akt1 in murine chondrocytes controls cartilage calcification during endochondral ossification under physiologic and pathologic conditions. Arthritis Rheum. 62, 826–836 (2010).
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