Author:
Zhu Bokai,Liu Silvia,David Natalie L.,Dion William,Doshi Nandini K.,Siegel Lauren B.,Amorim Tânia,Andrews Rosemary E.,Kumar G. V. Naveen,Li Hanwen,Irfan Saad,Pesaresi Tristan,Sharma Ankit X.,Sun Michelle,Fazeli Pouneh K.,Steinhauser Matthew L.
Abstract
AbstractMice and many marine organisms exhibit ~12-h ultradian rhythms, however, direct evidence of ~12-h ultradian rhythms in humans is lacking. Here, we performed prospective, temporal transcriptome profiling of peripheral white blood cells from three healthy humans. All three participants independently exhibited robust ~12-h transcriptional rhythms in molecular programs involved in RNA and protein metabolism, with strong homology to circatidal gene programs previously identified in Cnidarian marine species.
Funder
National Institute of Health
Office of Dietary Supplements
Publisher
Springer Science and Business Media LLC