A molecular threshold for effector CD8+ T cell differentiation controlled by transcription factors Blimp-1 and T-bet-Reference-Cited by-同舟云学术

A molecular threshold for effector CD8+ T cell differentiation controlled by transcription factors Blimp-1 and T-bet

Published:2016-03-07 Issue:4 Volume:17 Page:422-432
ISSN:1529-2908
Container-title:Nature Immunology
language:en
Short-container-title:Nat Immunol

Author:

Xin Annie,Masson Frederick,Liao Yang,Preston Simon,Guan Tianxia,Gloury Renee,Olshansky Moshe,Lin Jian-Xin,Li Peng,Speed Terence P,Smyth Gordon K^ORCID,Ernst Matthias,Leonard Warren J,Pellegrini Marc,Kaech Susan M,Nutt Stephen L,Shi Wei,Belz Gabrielle T,Kallies Axel

Publisher

Springer Science and Business Media LLC

Subject

Immunology,Immunology and Allergy

Link

http://www.nature.com/articles/ni.3410.pdf

Reference64 articles.

1. Belz, G.T. & Kallies, A. Effector and memory CD8+ T cell differentiation: toward a molecular understanding of fate determination. Curr. Opin. Immunol. 22, 279–285 (2010).

2. Kaech, S.M. & Cui, W. Transcriptional control of effector and memory CD8+ T cell differentiation. Nat. Rev. Immunol. 12, 749–761 (2012).

3. Chang, J.T., Wherry, E.J. & Goldrath, A.W. Molecular regulation of effector and memory T cell differentiation. Nat. Immunol. 15, 1104–1115 (2014).

4. Kaech, S.M. et al. Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells. Nat. Immunol. 4, 1191–1198 (2003).

5. Joshi, N.S. et al. Inflammation directs memory precursor and short-lived effector CD8+ T cell fates via the graded expression of T-bet transcription factor. Immunity 27, 281–295 (2007).

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