Controlled Fab-arm exchange for the generation of stable bispecific IgG1-Reference-Cited by-同舟云学术

Controlled Fab-arm exchange for the generation of stable bispecific IgG1

Published:2014-09-25 Issue:10 Volume:9 Page:2450-2463
ISSN:1754-2189
Container-title:Nature Protocols
language:en
Short-container-title:Nat Protoc

Author:

Labrijn Aran F,Meesters Joyce I,Priem Patrick,de Jong Rob N^ORCID,van den Bremer Ewald T J,van Kampen Muriel D,Gerritsen Arnout F,Schuurman Janine^ORCID,Parren Paul W H I

Publisher

Springer Science and Business Media LLC

Subject

General Biochemistry, Genetics and Molecular Biology

Link

http://www.nature.com/articles/nprot.2014.169.pdf

Reference31 articles.

1. Kontermann, R. Dual targeting strategies with bispecific antibodies. MAbs 4, 182–197 (2012).

2. Labrijn, A.F. et al. Species-specific determinants in the IgG CH3 domain enable Fab-arm exchange by affecting the noncovalent CH3-CH3 interaction strength. J. Immunol. 187, 3238–3246 (2011).

3. Schuurman, J. et al. Normal human immunoglobulin G4 is bispecific: it has two different antigen-combining sites. Immunology 97, 693–698 (1999).

4. van der Neut Kolfschoten, M. et al. Anti-inflammatory activity of human IgG4 antibodies by dynamic Fab arm exchange. Science 317, 1554–1557 (2007).

5. Gramer, M.J. et al. Production of stable bispecific IgG1 by controlled Fab-arm exchange: scalability from bench to large-scale manufacturing by application of standard approaches. MAbs 5, 962–973 (2013).

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