PET imaging of herpes simplex virus type 1 thymidine kinase (HSV1-tk) or mutant HSV1-sr39tk reporter gene expression in mice and humans using [18F]FHBG

Author:

Yaghoubi Shahriar S,Gambhir Sanjiv S

Publisher

Springer Science and Business Media LLC

Subject

General Biochemistry, Genetics and Molecular Biology

Reference47 articles.

1. Yaghoubi, S.S. & Gambhir., S.S. Measuring herpes simplex virus thymidine kinase reporter gene expression in vitro. Nat. Protocols. 1, 2137–2142 (2006).

2. Saito, Y. et al. Quantitative autoradiographic mapping of herpes simplex virus encephalitis with radiolabeled antiviral drug. Science 217, 1151–1153 (1982).

3. Tjuvajev, J.G. et al. Noninvasive imaging of herpes virus thymidine kinase gene transfer and expression: a potential method for monitoring clinical gene therapy. Cancer Res. 56, 4087–4095 (1996).

4. Gambhir, S.S. et al. Imaging of adenoviral-directed herpes simplex virus type 1 thymidine kinase reporter gene expression in mice with radiolabeled ganciclovir. J. Nucl. Med. 39, 2003–2011 (1998).

5. Ponomarev, V. et al. A novel triple-modality reporter gene for whole-body fluorescent, bioluminescent, and nuclear noninvasive imaging. Eur. J. Nucl. Med. Mol. Imaging 31, 740–751 (2004).

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