The validated embryonic stem cell test to predict embryotoxicity in vitro

Author:

Seiler Andrea E M,Spielmann Horst

Publisher

Springer Science and Business Media LLC

Subject

General Biochemistry, Genetics and Molecular Biology

Reference59 articles.

1. Schaefer, C., Peters, P.W.J. & Miller, R.K. Drugs During Pregnancy and Lactation (Elsevier, Academic Press, 2007).

2. International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH). ICH harmonized tripartite guideline: detection of toxicity to human reproduction for medicinal products & toxicity to male fertility (S5 (R2)). Current Step 4 version. (1993). http://www.ich.org/fileadmin/Public_Web_Site/ICH_Products/Guidelines/Safety/S5_R2/Step4/S5_R2__Guideline.pdf .

3. Spielmann, H., Pohl, I., Döring, B., Liebsch, M. & Moldenhauer, F. The embryonic stem cell test (EST), an in vitro embryotoxicity test using two permanent mouse cell lines: 3T3 fibroblasts and embryonic stem cells. In Vitro Toxicol. 10, 119–127 (1997).

4. Hoffman, J.A. & Merrill, B.J. New and renewed perspectives on embryonic stem cell pluripotency. Front. Biosci. 12, 3321–3332 (2007).

5. Keller, G. Embryonic stem cell differentiation: emergence of a new era in biology and medicine. Genes Dev. 19, 1129–1155 (2005).

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