Synthesis of all-hydrocarbon stapled α-helical peptides by ring-closing olefin metathesis
Author:
Publisher
Springer Science and Business Media LLC
Subject
General Biochemistry, Genetics and Molecular Biology
Link
http://www.nature.com/articles/nprot.2011.324.pdf
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3. Henchey, L.K., Jochim, A.L. & Arora, P.S. Contemporary strategies for the stabilization of peptides in the alpha-helical conformation. Curr. Opin. Chem. Biol 12, 692–697 (2008).
4. Schafmeister, C.E., Po, J. & Verdine, G.L. An all-hydrocarbon cross-linking system for enhancing the helicity and metabolic stability of peptides. J. Am. Chem. Soc. 122, 5891–5892 (2000).
5. Blackwell, H.E. & Grubbs, R.H. Highly efficient synthesis of covalently crosslinked peptide helices by ring-closing metathesis. Angew. Chem. Int. Ed. 37, 3281–3284 (1998).
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