A quantitative high-throughput 96-well plate fluorescence assay for mechanism-based inactivators of cytochromes P450 exemplified using CYP2B6
Author:
Publisher
Springer Science and Business Media LLC
Subject
General Biochemistry, Genetics and Molecular Biology
Link
http://www.nature.com/articles/nprot.2010.125.pdf
Reference17 articles.
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4. Kent, U.M. et al. Mechanism-based inactivators as probes of cytochrome P450 structure and function. Curr. Drug Metab. 2, 215–243 (2001).
5. Hollenberg, P.F. et al. Mechanism-based inactivation of human cytochrome P450s: experimental characterization, reactive intermediates, and clinical implications. Chem. Res. Toxicol. 21, 189–205 (2008).
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