Protocols to detect senescence-associated beta-galactosidase (SA-βgal) activity, a biomarker of senescent cells in culture and in vivo-Reference-Cited by-同舟云学术

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Protocols to detect senescence-associated beta-galactosidase (SA-βgal) activity, a biomarker of senescent cells in culture and in vivo

Published:2009-11-19 Issue:12 Volume:4 Page:1798-1806
ISSN:1754-2189
Container-title:Nature Protocols
language:en
Short-container-title:Nat Protoc

Author:

Debacq-Chainiaux Florence,Erusalimsky Jorge D,Campisi Judith,Toussaint Olivier

Publisher

Springer Science and Business Media LLC

Subject

General Biochemistry, Genetics and Molecular Biology

Link

http://www.nature.com/articles/nprot.2009.191.pdf

Reference35 articles.

1. Shay, J.W. & Wright, W.E. Hayflick, his limit, and cellular ageing. Nat. Rev. Mol. Cell Biol. 1, 72–76 (2000).

2. Campisi, J. & d'Adda di Fagagna, F. Cellular senescence: when bad things happen to good cells. Nat. Rev. Mol. Cell Biol. 8, 729–740 (2007).

3. Chretien, A. et al. Role of TGF-beta1-independent changes in protein neosynthesis, p38alphaMAPK, and cdc42 in hydrogen peroxide-induced senescence-like morphogenesis. Free Radic. Biol. Med. 44, 1732–1751 (2008).

4. Collado, M., Blasco, M.A. & Serrano, M. Cellular senescence in cancer and aging. Cell 130, 223–233 (2007).

5. Price, J.S. et al. The role of chondrocyte senescence in osteoarthritis. Aging Cell 1, 57–65 (2002).

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