Heterologous expression of diverse propionyl-CoA carboxylases affects polyketide production in Escherichia coli-Reference-Cited by-同舟云学术

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Heterologous expression of diverse propionyl-CoA carboxylases affects polyketide production in Escherichia coli

Published:2017-04-12 Issue:7 Volume:70 Page:859-863
ISSN:0021-8820
Container-title:The Journal of Antibiotics
language:en
Short-container-title:J Antibiot

Author:

Vandova Gergana A,O'Brien Robert V,Lowry Brian,Robbins Thomas F,Fischer Curt R,Davis Ronald W,Khosla Chaitan,Harvey Colin JB,Hillenmeyer Maureen E

Publisher

Springer Science and Business Media LLC

Subject

Drug Discovery,Pharmacology

Link

http://www.nature.com/articles/ja201738.pdf

Reference29 articles.

1. Cane, D. E., Walsh, C. T. & Khosla, C. Harnessing the biosynthetic code: combinations, permutations, and mutations. Science 282, 63–68 (1998).

2. O'Brien, R. V., Davis, R. W., Khosla, C. & Hillenmeyer, M. E. Computational identification and analysis of orphan assembly-line polyketide synthases. J. Antibiot. 67, 89–97 (2014).

3. Hillenmeyer, M. E., Vandova, G. A., Berlew, E. E. & Charkoudian, L. K. Evolution of chemical diversity by coordinated gene swaps in type II polyketide gene clusters. Proc. Natl Acad. Sci. USA 112, 13952–13957 (2015).

4. Pfeifer, B. A. & Khosla, C. Biosynthesis of polyketides in heterologous hosts. Microbiol. Mol. Biol. Rev. 65, 106–118 (2001).

5. Gao, X., Wang, P. & Tang, Y. Engineered polyketide biosynthesis and biocatalysis in Escherichia coli. Appl. Microbiol. Biotechnol. 88, 1233–1242 (2010).

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