Heterocyclyl tetracyclines. 2. 7-Methoxy-8-pyrrolidinyltetracyclines: discovery of TP-2758, a potent, orally efficacious antimicrobial against Gram-negative pathogens

Author:

Sun Cuixiang,Deng Yonghong,Hunt Diana K,Fyfe Corey,Chen Chi-Li,Clark Roger B,Grossman Trudy H,Sutcliffe Joyce A,Xiao Xiao-Yi

Publisher

Springer Science and Business Media LLC

Subject

Drug Discovery,Pharmacology

Reference23 articles.

1. Centers for Disease Control and Prevention (CDC) 2013 Antibiotic resistance threats in the United States, 2013 http://www.cdc.gov/drugresistance/threat-report-2013 .

2. The PEW Charitable Trusts Antibiotics currently in clinical development. December 2016 http://www.pewtrusts.org/~/media/assets/2016/12/antibiotics_datatable_201612.pdf?la=en .

3. Cain, R., Narramore, S., McPhillie, M., Simmons, K. & Fishwick, C. W. Applications of structure-based design to antibacterial drug discovery. Bioorg. Chem. 55, 69–76 (2014).

4. Katz, L. & Baltz, R. H. Natural product discovery: past, present, and future. J. Ind. Microbiol. Biotechnol. 43, 155–176 (2016).

5. Silver, L. L. Natural products as a source of drug leads to overcome drug resistance. Future Microbiol. 10, 1711–1718 (2015).

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