Enantiospecific total synthesis of the squalene synthase inhibitors (–)-CJ-13,982 and its enantiomer from a common intermediate
Author:
Publisher
Springer Science and Business Media LLC
Subject
Drug Discovery,Pharmacology
Link
http://www.nature.com/articles/ja2017127.pdf
Reference18 articles.
1. Rizzacasa, M. A. & Sturgess, D. Total synthesis of alkyl citrate natural products. Org. Biomol. Chem. 12, 1367–1382 (2014).
2. Watanabe, S. et al. CJ-13,981 and CJ-13,982, new squalene synthase inhibitors. J. Antibiot. 54, 1025–1030 (2001).
3. Harris, G. H. et al. Isolation, structure determination and squalene synthase activity of L-731,120 and L-731,128, alkyl citrate analogs of zaragozic acids A and B. Bioorg. Med. Chem. Lett. 5, 2403–2408 (1995).
4. Bergstrom, J. D. et al. Zaragozic acids: a family of fungal metabolites that are picomolar competitive inhibitors of squalene synthase. Proc. Natl Acad. Sci. USA 90, 80–84 (1993).
5. Hensens, O. D., Dufresne, C., Liesch, J. M. & Zink, D. L. The zaragozic acids: structure elucidation of a new class of squalene synthase inhibitors. Tetrahedron Lett. 34, 399–402 (1993).
Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. In vitro studies of maleidride-forming enzymes;RSC Advances;2021
2. Synthesis of Alkyl Citrates (−)-CJ-13,981, (−)-CJ-13,982, and (−)-L-731,120 via a Cyclobutene Diester;Organic Letters;2018-06-28
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