Cathepsin S attenuates endosomal EGFR signalling: A mechanical rationale for the combination of cathepsin S and EGFR tyrosine kinase inhibitors
Author:
Publisher
Springer Science and Business Media LLC
Subject
Multidisciplinary
Link
http://www.nature.com/articles/srep29256.pdf
Reference47 articles.
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3. Hyatt, D. C. & Ceresa, B. P. Cellular localization of the activated EGFR determines its effect on cell growth in MDA-MB-468 cells. Exp Cell Res 314, 3415–3425 (2008).
4. Sousa, L. P. et al. Suppression of EGFR endocytosis by dynamin depletion reveals that EGFR signaling occurs primarily at the plasma membrane. Proc Natl Acad Sci USA 109, 4419–4424 (2012).
5. Taub, N., Teis, D., Ebner, H. L., Hess, M. W. & Huber, L. A. Late endosomal traffic of the epidermal growth factor receptor ensures spatial and temporal fidelity of mitogen-activated protein kinase signaling. Mol Biol Cell 18, 4698–4710 (2007).
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