Extrachromosomal DNA in cancer
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Publisher
Springer Science and Business Media LLC
Link
https://www.nature.com/articles/s41568-024-00669-8.pdf
Reference115 articles.
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3. Hoff, D. D. V., Needham-VanDevanter, D. R., Yucel, J., Windle, B. E. & Wahl, G. M. Amplified human MYC oncogenes localized to replicating submicroscopic circular DNA molecules. Proc. Natl Acad. Sci. USA 85, 4804–4808 (1988).
4. Wu, S. et al. Circular ecDNA promotes accessible chromatin and high oncogene expression. Nature 575, 699–703 (2019). This study utilize a multidisciplinary approach combining ultrastructural imaging, long-range optical mapping and computational analysis of whole-genome sequencing to reveal that oncogenes carried on ecDNA in cancer have high expression, owing to the enhanced accessibility of ecDNA and ultra-long-range active chromatin contacts.
5. Kim, H. et al. Extrachromosomal DNA is associated with oncogene amplification and poor outcome across multiple cancers. Nat. Genet. 52, 891–897 (2020). This study, based on computational analysis of WGS data from 3,212 patients with cancer, reveals that ecDNA amplification is a common phenomenon in various cancer types that results in enhanced oncogene transcription, chromatin accessibility and poor patient survival.
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