Nucleotide metabolism: a pan-cancer metabolic dependency
Author:
Publisher
Springer Science and Business Media LLC
Subject
General Earth and Planetary Sciences,General Environmental Science
Link
https://www.nature.com/articles/s41568-023-00557-7.pdf
Reference157 articles.
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2. Li, L. et al. Identification of DHODH as a therapeutic target in small cell lung cancer. Sci. Transl Med. 11, 517 (2019).
3. Zhu, X. G. et al. Functional genomics in vivo reveal metabolic dependencies of pancreatic cancer cells. Cell Metab. 33, 211–221 (2021).
4. Sykes, D. B. et al. Inhibition of dihydroorotate dehydrogenase overcomes differentiation blockade in acute myeloid leukemia. Cell 167, 171–186.e15 (2016). This study demonstrated the potential of DHODH inhibitors to induce leukaemia differentiation and sparked renewed clinical interest in DHODH inhibitors to treat cancer.
5. Koundinya, M. et al. Dependence on the pyrimidine biosynthetic enzyme DHODH is a synthetic lethal vulnerability in mutant KRAS-driven cancers. Cell Chem. Biol. 25, 705–717.e11 (2018).
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