Targeting the DNA damage response in immuno-oncology: developments and opportunities
Author:
Publisher
Springer Science and Business Media LLC
Subject
General Earth and Planetary Sciences,General Environmental Science
Link
https://www.nature.com/articles/s41568-021-00386-6.pdf
Reference246 articles.
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4. Le, D. T. et al. Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade. Science 357, 409–413 (2017). This study reports that MMR deficiency results in increased tumour immunogenicity and response to anti-PD1/anti-PDL1 therapy regardless of the cancer type.
5. Mouw, K. W., Goldberg, M. S., Konstantinopoulos, P. A. & D’Andrea, A. D. DNA damage and repair biomarkers of immunotherapy response. Cancer Discov. 7, 675–693 (2017).
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