Author:
Zhu Xiaolin,Zhang Kexin,Wang Chengzhi,Guan Jiunian,Yuan Xing,Li Baikun
Abstract
AbstractThis study aimed at developing simple, sensitive and rapid electrochemical
approach to quantitatively determine and assess the toxicity of 2,4-dichlorophenol
(2,4-DCP), a priority pollutant and has potential risk to public health through a
novel poly(eosin Y, EY)/hydroxylated multi-walled carbon nanotubes composite
modified electrode (PEY/MWNTs-OH/GCE). The distinct feature of this easy-fabricated
electrode was the synergistic coupling effect between EY and MWNTs-OH that enabled a
high electrocatalytic activity to 2,4-DCP. Under optimum conditions, the oxidation
peak current enhanced linearly with concentration increasing from 0.005 to 0.1 μM
and 0.2 to 40.0 μM, and revealed the detection limit of 1.5 nM. Moreover, the
PEY/MWNTs-OH/GCE exhibited excellent electrocatalytic activity toward intracellular
electroactive species. Two sensitive electrochemical signals ascribed to
guanine/xanthine and adenine/hypoxanthine in human hepatoma (HepG2) cells were
detected simultaneously. The sensor was successfully applied to evaluate the
toxicity of 2,4-DCP to HepG2 cells. The IC50 values based on
the two electrochemical signals are 201.07 and 252.83 μM, respectively. This study
established a sensitive platform for the comprehensive evaluation of 2,4-DCP and
posed a great potential to simplify environmental toxicity monitoring.
Publisher
Springer Science and Business Media LLC
Cited by
23 articles.
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