1. Bower M, Newlands ES, Bleehen NM, Brada M, Begent RJ, Calvert H, Colquhoun I, Lewis P, Brampton MH (1997) Multicentre CRC phase II trial of temozolomide in recurrent or progressive high-grade glioma. Cancer Chemother Pharmacol 40: 484–488
2. Brock CS, Newlands ES, Wedge SR, Bower M, Evans H, Colquhoun I, Roddie M, Glaser M, Brampton MH, Rustin GJ (1998) Phase I trial of temozolomide using an extended continuous oral schedule. Cancer Res 58: 4363–4367
3. Denis LJ, Tolcher A, Figueroa JA, Drengler R, Geyer C, Eckhardt SG, Cutler Dl, Reyderman L, Von Hoff DD, Rowinsky EK (2000) Protracted daily administration of temozolomide is feasible: a phase I and pharmacokinetic – pharmacodynamic study. Proc Am Soc Clin Oncol 19: 202a
4. Dolan ME, Moschel RC, Pegg AE (1990) Depletion of mammalian O6-alkylguanine-DNA alkyltransferase activity by O6-benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic alkylating agents. Proc Nat Acad Sci USA 87: 5368–5372
5. Dumenco LL, Warman B, Hatzoglou M, Lim IK, Abboud SL, Gerson SL (1989) Increase in nitrosourea resistance in mammalian cells by retrovirally mediated gene transfer of bacterial O6-alkylguanine-DNA alkyltransferase. Cancer Res 49: 6044–6051