R306465 is a novel potent inhibitor of class I histone deacetylases with broad-spectrum antitumoral activity against solid and haematological malignancies

Author:

Arts J,Angibaud P,Mariën A,Floren W,Janssens B,King P,van Dun J,Janssen L,Geerts T,Tuman R W,Johnson D L,Andries L,Jung M,Janicot M,van Emelen K

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Oncology

Reference38 articles.

1. Arts J, De Schepper S, Van Emelen K (2003) Histone deacetylase inhibitors: from chromatin remodeling to experimental cancer therapeutics. Curr Med Chem 10 (22): 2343–2350

2. Bali P, Pranpat M, Bradner J, Balasis M, Fiskus W, Guo F, Rocha K, Kumaraswamy S, Boyapalle S, Atadja P, Seto E, Bhalla K (2005) Inhibition of histone deacetylase 6 acetylates and disrupts the chaperone function of heat shock protein 90. J Biol Chem 280: 26729–26734

3. Belien A, De Schepper S, Floren W, Janssens B, Marien A, King P, Van Dun J, Andries L, Voeten J, Bijnens L, Janicot M, Arts J (2006) Real-time gene expression analysis in human xenografts for evaluation of histone deacetylase inhibitors. Mol Cancer Ther 5 (9): 2317–2323

4. Blagosklonny MV, Robey R, Sackett DL, Du L, Traganos F, Darzynkiewicz Z, Fojo T, Bates SE (2002) Histone deacetylase inhibitors all induce p21 but differentially cause tubulin acetylation, mitotic arrest, and cytotoxicity. Mol Cancer Ther 1: 937–941

5. Butler LM, Agus DB, Scher HI, Higgins B, Rose A, Cordon-Cardo C, Thaler HT, Rifkind RA, Marks PA, Richon VM (2000) Suberoylanilide hydroxamic acid, an inhibitor of histone deacetylase, suppresses the growth of prostate cancer cells in vitro and in vivo. Cancer Res 60 (18): 5165–5170

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