Src tyrosine kinase augments taxotere-induced apoptosis through enhanced expression and phosphorylation of Bcl-2

Author:

Boudny V,Nakano S

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Oncology

Reference39 articles.

1. Barnekow A, Paul E & Manfred S (1989) Expression of the c-src protooncogene in human skin tumors. Cancer Res 47: 235–230

2. Blagosklonny MV, Schulte TW, Nguyen P, Trepel J & Neckers LM (1996) Taxol-induced apoptosis and phosphorylation of Bcl-2 protein involves c-Raf-1 and represents a novel c-Raf-1 signal transduction pathway. Cancer Res 56: 1851–1854

3. Blagosklonny MV, Giannakakou P, El-Deiry WS, Kingston DJI, Higgs PI, Neckers LM & Fojo T (1997) Raf-1/Bcl-2 phosphorylation: a step from microtubule damage to cell death. Cancer Res 57: 130–135

4. Blagosklonny MV, Chuman Y, Bergan RC & Fojo T (1999) Mitogen-activated protein kinase pathway is dispensable for microtubule-active drug-induced Raf-1/Bcl-2 phosphorylation and apoptosis in leukemia cells. Leukemia 13: 1028–1036

5. Bolen JB, Veillette A, Schwartz AM, DeSeau V & Rosen N (1987) Activation of pp60c-src protein kinase activity in human colon carcinoma. Proc Natl Acad Sci USA 84: 2251–2255

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