Antiangiogenic activity of aplidine, a new agent of marine origin

Author:

Taraboletti G,Poli M,Dossi R,Manenti L,Borsotti P,Faircloth G T,Broggini M,D'Incalci M,Ribatti D,Giavazzi R

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Oncology

Reference40 articles.

1. Albella B, Faircloth G, Lopez-Lazaro L, Guzman C, Jimeno J, Bueren JA (2002) In vitro toxicity of ET-743 and aplidine, two marine-derived antineoplastics, on human bone marrow haematopoietic progenitors. Comparison with the clinical results. Eur J Cancer 38: 1395–1404

2. Armand JP, Ady-Vago N, Faivre S, Chieze S, Baudin E, Ribrag V, Lecot F, Iglesias L, Lopez-Lazaro L, Guzman C, Jimeno J, Ducreux M, Le Chevalier T, Raymond E (2002) Phase I and pharmacokinetic study of aplidine (APL) given as a 24-hour continuous infusion every other week (q2w)in patients (pts) with solid tumor (ST) and lymphoma (NHL). Proc Am Soc Clin Oncol 20: 120a

3. Belotti D, Vergani V, Drudis T, Borsotti P, Pitelli MR, Viale G, Giavazzi R, Taraboletti G (1996) The microtubule-affecting drug paclitaxel has antiangiogenic activity. Clin Cancer Res 2: 1843–1849

4. Broggini M, Marchini SV, Galliera E, Borsotti P, Taraboletti G, Erba E, Sironi M, Jimeno J, Faircloth GT, Giavazzi R, D'Incalci M (2003) Aplidine, a new anticancer agent of marine origin, inhibits vascular endothelial growth factor (VEGF) secretion and blocks VEGF-VEGFR-1 (flt-1) autocrine loop in human leukemia cells MOLT-4. Leukemia 17: 52–59

5. Carmeliet P, Jain RK (2000) Angiogenesis in cancer and other diseases. Nature 407: 249–257

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