Role of platelet-derived endothelial cell growth factor/thymidine phosphorylase in fluoropyrimidine sensitivity

Author:

de Bruin M,van Capel T,Van der Born K,Kruyt F A,Fukushima M,Hoekman K,Pinedo H M,Peters G J

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Oncology

Reference51 articles.

1. Ackland SP, Peters GJ (1999) Thymidine phosphorylase: its role in sensitivity and resistance to anticancer drugs. Drug Resist Updat 2: 205–214

2. Ansfield FJ, Ramirez G (1971) Phase I and II studies of 2′-deoxy-5-(trifluoromethyl)-uridine (NSC- 75520). Cancer Chemother Rep 55: 205–208

3. Cao D, Russell RL, Zhang D, Leffert JJ, Pizzorno G (2002) Uridine phosphorylase (−/−) murine embryonic stem cells clarify the key role of this enzyme in the regulation of the pyrimidine salvage pathway and in the activation of fluoropyrimidines. Cancer Res 62: 2313–2317

4. Ciccolini J, Cuq P, Evrard A, Giacometti S, Pelegrin A, Aubert C, Cano JP, Milano G, Iliadis A (2001) Combination of thymidine phosphorylase gene transfer and deoxinosine treatment greatly enhances 5-fluorouracil antitumor activity in vitro and in vivo. Mol Cancer Ther 1: 133–139

5. Crawford EL, Peters GJ, Noordhuis P, Rots MG, Vondracek M, Grafstrom RC, Lieuallen K, Lennon G, Zahorchak RJ, Georgeson MJ, Wali A, Lechner JF, Fan PS, Kahaleh MB, Khuder SA, Warner KA, Weaver DA, Willey JC (2001) Reproducible gene expression measurement among multiple laboratories obtained in a blinded study using standardized RT (StaRT)-PCR. Mol Diagn 6: 217–225

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