Phase I and pharmacokinetic study of the combination of topotecan and ifosfamide administered intravenously every 3 weeks

Author:

Kerbusch T,Groenewegen G,Mathôt R A A,Herben V M M,ten Bokkel Huinink W W,Swart M,Ambaum B,Rosing H,Jansen S,Voest E E,Beijnen J H,Schellens J H M

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Oncology

Reference25 articles.

1. Bienvenu BJ, Soinet SL, Tong W, Aghajanianh C, Waltzman R, Peyton M, Pezzuli S, Spriggs D (2000) Phase I dose escalation study of topotecan and ifosfamide in patients with refractory non-haematological malignancies. Proc Am Assoc Cancer Res 41: 223 (abstract 871)

2. Boeckman AJ, Sheiner LW, Beal SL (1994) NONMEM Users Guide – Part V: Introductory Guide. San Francisco, USA: NONMEM Project Group, University of California

3. Cerny T, Küpfer A (1992) The enigma of ifosfamide encephalopathy. Ann Oncol 3: 679–681

4. Creemers GJ, Wanders J, Gamucci T, Vallentin S, Dirix LY, Schoffski P, Hudson I, Verweij J (1995) Topotecan in colorectal cancer: a phase II study of the EORTC early clinical trials group. Ann Oncol 6 (Suppl): 844–846

5. Gallo JM, Laub PB, Rowinsky EK, Grochow LB, Baker SD (2000) Population pharmacokinetic model for topotecan derived from phase I clinical trials. J Clin Oncol 18: 2459–2467

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