PD 098059, an inhibitor of ERK1 activation, attenuates the in vivo invasiveness of head and neck squamous cell carcinoma

Author:

Simon C,Hicks M J,Nemechek A J,Mehta R,Jr B W O’Malley,Goepfert H,Flaitz C M,Boyd D

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Oncology

Reference46 articles.

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2. Agarwal, S., Corbley, M. J. & Roberts, T. M. (1995). Reconstitution of signal transduction from the membrane to the nucleus in a baculovirus expression system: activation of raf-1 leads to hypermodification of c-jun and c-fos via multiple pathways. Oncogene 11: 427–438.

3. Alessi, D. R., Cuenda, A., Cohen, P., Dudley, D. T. & Saltiel, A. R. (1995). PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo. J Biol Chem 270: 27489–27494.

4. Anderson, I. C., Shipp, M. A., Docherty, A. J. P. & Teicher, B. A. (1996). Combination therapy including a gelatinase inhibitor and cytotoxic agent reduces local invasion and metastasis of murine Lewis lung carcinoma. Cancer Res 56: 715–718.

5. Auble, D. T. & Brinckerhoff, C. E. (1991). The AP-1 sequence is necessary but not sufficient for phorbol induction of collagenase in fibroblasts. Biochemistry 30: 4629–4635.

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