Targeting DXP synthase in human pathogens: enzyme inhibition and antimicrobial activity of butylacetylphosphonate-Reference-Cited by-同舟云学术

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Targeting DXP synthase in human pathogens: enzyme inhibition and antimicrobial activity of butylacetylphosphonate

Published:2013-10-30 Issue:1 Volume:67 Page:77-83
ISSN:0021-8820
Container-title:The Journal of Antibiotics
language:en
Short-container-title:J Antibiot

Author:

Smith Jessica M,Warrington Nicole V,Vierling Ryan J,Kuhn Misty L,Anderson Wayne F,Koppisch Andrew T,Freel Meyers Caren L

Publisher

Springer Science and Business Media LLC

Subject

Drug Discovery,Pharmacology

Link

http://www.nature.com/articles/ja2013105.pdf

Reference54 articles.

1. Arigoni, D. et al. Terpenoid biosynthesis from 1-deoxy-D-xylulose in higher plants by intramolecular skeletal rearrangement. Proc. Natl Acad. Sci. USA 94, 10600–10605 (1997).

2. Rohmer, M., Knani, M., Simonin, P., Sutter, B. & Sahm, H. Isoprenoid biosynthesis in bacteria: a novel pathway for the early steps leading to isopentenyl diphosphate. Biochem. J. 15, 517–524 (1993).

3. Walsh, C. T. Antibiotics: Actions, Origins, Resistance, ASM Press: Washington, DC, USA, (2003).

4. Sprenger, G. A. et al. Identification of a thiamin-dependent synthase in Escherichia coli required for the formation of the 1-deoxy-D-xylulose 5-phosphate precursor to isoprenoids, thiamin, and pyridoxol. Proc. Natl Acad. Sci. USA 94, 12857–12862 (1997).

5. Lois, L. M. et al. Cloning and characterization of a gene from Escherichia coli encoding a transketolase-like enzyme that catalyzes the synthesis of D-1-deoxyxylulose 5-phosphate, a common precursor for isoprenoid, thiamin, and pyridoxol biosynthesis. Proc. Natl Acad. Sci. USA 95, 2105–2110 (1998).

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1. An activity-based probe for antimicrobial target DXP synthase, a thiamin diphosphate-dependent enzyme;Frontiers in Chemical Biology;2024-05-07

2. Investigating inhibitors of 1-deoxy- d -xylulose 5-phosphate synthase in a mouse model of UTI;Microbiology Spectrum;2024-04-02

3. 1-deoxy-D-xylulose-5-phosphate synthase from Pseudomonas aeruginosa and Klebsiella pneumoniae reveals conformational changes upon cofactor binding;Journal of Biological Chemistry;2023-09

4. Structure of Mycobacterium tuberculosis 1-Deoxy-D-Xylulose 5-Phosphate Synthase in Complex with Butylacetylphosphonate;Crystals;2023-04-27

5. DXP Synthase Function in a Bacterial Metabolic Adaptation and Implications for Antibacterial Strategies;Antibiotics;2023-04-01

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