Hypoxia induces chemoresistance to proteasome inhibitors through orchestrating deSUMOylation and ubiquitination of SRC-3 in multiple myeloma

Author:

Guo Jing,Lv Yangyang,Wang Sheng,Peng Ziyi,Xie Ying,Wang Yixuan,Jiang Hongmei,Li Xin,Wang Mengqi,Hu Meilin,Mu Jiangpeng,Wang Jingya,Xie Yangyang,Cheng Xiankui,Zhao ZhigangORCID,Liu ZhiqiangORCID

Funder

National Natural Science Foundation of China

Natural Science Foundation of Beijing Municipality

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Genetics,Molecular Biology

Reference38 articles.

1. van de Donk N, Pawlyn C, Yong KL. Multiple myeloma. Lancet 2021;397:410–27.

2. Moser-Katz T, Joseph NS, Dhodapkar MV, Lee KP, Boise LH. Game of bones: how myeloma manipulates its microenvironment. Front Oncol. 2020;10:625199.

3. Kumar SK, Rajkumar V, Kyle RA, van Duin M, Sonneveld P, Mateos MV, et al. Multiple myeloma. Nat Rev Dis Prim. 2017;3:17046.

4. From the American Association of Neurological Surgeons ASoNC, Interventional Radiology Society of Europe CIRACoNSESoMINTESoNESOSfCA, Interventions SoIRSoNS, World Stroke O, Sacks D, Baxter B, et al. Multisociety consensus quality improvement revised consensus statement for endovascular therapy of acute ischemic stroke. Int J Stroke. 2018;13:612–32.

5. Ikeda S, Tagawa H. Impact of hypoxia on the pathogenesis and therapy resistance in multiple myeloma. Cancer Sci. 2021;112:3995–4004.

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