Dynamics of an epigenetic regulator on chromatin observed at the single-molecule level
Author:
Publisher
Springer Science and Business Media LLC
Link
https://www.nature.com/articles/s41594-024-01374-8.pdf
Reference5 articles.
1. Lewis, J. D. et al. Purification, sequence, and cellular localization of a novel chromosomal protein that binds to methylated DNA. Cell 69, 905–914 (1992). This paper reports the detection of MeCP2 in nuclear extracts and its methyl-CpG binding activity.
2. Amir, R. E. et al. Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2. Nat. Genet. 23, 185–188 (1999). This paper reports the first mutations of the MECP2 gene, located on the X chromosome, as the cause of RTT.
3. Lombardi, L. M., Baker, S. A. & Zoghbi, H. Y. MECP2 disorders: from the clinic to mice and back. J. Clin. Invest. 125, 2914–2923 (2015). A review article that presents the molecular function of MeCP2, the clinical profiles of RTT and MECP2 duplication syndrome and therapeutic strategies for these disorders.
4. Connolly, D. R. & Zhou, Z. Genomic insights into MeCP2 function: a role for the maintenance of chromatin architecture. Curr. Opin. Neurobiol. 59, 174–179 (2019). A review article that presents MeCP2’s context-specific gene regulatory functions and proposes a model in which MeCP2 serves as a global organizer of chromatin architecture.
5. Chua, G. N. L. & Liu, S. When force met fluorescence: single-molecule manipulation and visualization of protein-DNA interactions. Annu. Rev. Biophys. 53, 169–191 (2024). A review article that presents single-molecule correlative force and fluorescence microscopy and its use in imaging protein dynamics on DNA and chromatin.
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线，采集、加工和组织学术论文而形成的新型学术文献查询和分析系统，可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容，当前同舟云学术共收录了国内外主流学术期刊6万余种，收集的期刊论文及会议论文总量共计约1.5亿篇，并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询！咨询电话：010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3