Cryo-EM reveals the transition of Arp2/3 complex from inactive to nucleation-competent state
Author:
Publisher
Springer Science and Business Media LLC
Subject
Molecular Biology,Structural Biology
Link
https://www.nature.com/articles/s41594-020-0481-x.pdf
Reference56 articles.
1. Goley, E. D. & Welch, M. D. The ARP2/3 complex: an actin nucleator comes of age. Nat. Rev. Mol. Cell Biol. 7, 713–726 (2006).
2. Higgs, H. N. & Pollard, T. D. Regulation of actin polymerization by Arp2/3 complex and WASp/Scar proteins. J. Biol. Chem. 274, 32531–32534 (1999).
3. Wagner, A. R., Luan, Q., Liu, S.-L. & Nolen, B. J. Dip1 defines a class of Arp2/3 complex activators that function without preformed actin filaments. Curr. Biol. 23, 1990–1998 (2013).
4. Goley, E. D., Rodenbusch, S. E., Martin, A. C. & Welch, M. D. Critical conformational changes in the Arp2/3 complex are induced by nucleotide and nucleation promoting factor. Mol. Cell 16, 269–279 (2004).
5. Rodal, A. A. et al. Conformational changes in the Arp2/3 complex leading to actin nucleation. Nat. Struct. Mol. Biol. 12, 26–31 (2005).
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